Lloyd Brothers Specific Medicine Cannabis Tincture Bottle

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The threshold for typical psychic effects of cannabis lies in the range of about 0.2 to 0.3 mg delta9-THC/kg body weight or 5 to 10 mg/m2 body surface area, respectively, or about 10 to 15 mg THC in an adult. However, this threshold may occasionally be lower, 5 mg THC per single dose, particularly in older individuals. Pronounced psychic effects after oral application are expected above 0.4 mg/kg. With inhalation, the threshold for perceivable effects may be lower, 5 mg or less.

Interindividual responsiveness is often very variable for therapeutic effects as well. Therefore, the optimal individual dose has to be ascertained. If possible, slowly increasing doses should be applied to avoid undesirable side effects, above all effects on psyche and circulation. Starting doses are 2 X 2.5 mg or 2 X 5 mg THC per day. Depending on need, dosages may be increased up to 5 X 10 mg/day or more. In some indications for therapeutic cannabis the starting doses remain sufficient, while in others, higher doses are required.

If natural cannabis products of unknown THC content are used orally, the patient should begin with about 0.05 to 0.1 g of the drug (for cannabis with an average THC content of 5 percent this corresponds to 2.5 to 5 mg THC) and increase slowly up to the desired or tolerated dose, respectively. With inhalation, one puff should be taken at first, followed by a period of pausing for several minutes to observe the effect. In this manner, the drug effect can easily titrated. The customary psychotropic effects of cannabis may be tolerable with acute treatment in some contexts, such as in the treatment of a migraine attack. Side effects may also be avoided with oral administration before bed, e.g., to prevent nocturnal spasms in MS patients.

Tolerance develops to the psychic and cardiac effects of cannabis within some days or weeks of chronic usage, so that daily doses of more than 50 mg THC may sometimes be taken without relevant psychic side effects. Tolerance may remain for a relatively long period (weeks to months) after quitting the drug. Tolerance may also arise with respect to therapeutically desired effects and prompt an increase in dose. Alternatively, a cessation of cannabis therapy for a period of two to three months with change to another drug may be considered.

Excerpt from Grotenhermen and Russo's (Eds.) Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential (2002, pp. 345-346).

Images from Antique Cannabis Book CD Rom

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